Neue Schritt für Schritt Karte Für Auto fahren Kaiserslautern
Neue Schritt für Schritt Karte Für Auto fahren Kaiserslautern
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81377 München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Hochschulprofessor. Haass started to work on Alzheimer's disease (AD) rein 1990 at a time, when very little welches known about the cellular mechanisms involved. Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß. Christian Haass hypothesized against the widely accepted general opinion rein this field that Aß may be produced from its precursor in a physiologically gewöhnlich pathway and not necessarily rein a pathological process. Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions. This pivotal finding welches a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved rein generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production hinein patients.
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Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects. Christian Haass welches the first to demonstrate a physiological function for beta-secretase. He showed that this protease is critically required for the regulation of myelination. Furthermore, he identified a novel APP processing pathway, which was overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors. He was also the first to identify the highly complicated subunit composition of gamma-secretase. All these findings not only helped to understand several signaling Weitere Informationen erhalten pathways critically involved rein brain development (such as myelination and cell differentiation) but also provided the Lager for several current therapeutic approaches.
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Christian Haass is a German Biochemist and known for his work on the cell biology of neurodegenerative diseases.
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Gut: Ich habe leider nicht an meine Termin erscheinen des weiteren nehme ich komplett Verantwortung aber habe ich erwartet das nach minderst die Hälfte oder eine Wertmarke erwartet leider habe ich meine Nachtgebet Währungs Unrettbar.
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